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Cardiac_Progenitor_Summary - Tissue Engineering Cardiac...

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Tissue Engineering: Cardiac Progenitor Cells The field of Cardiac Tissue Engineering is one of infinite possibilities. A variety of cell types studied for use in generating replacement or repair tissues have demonstrated positive results. Tissues constructed from mammalian cardiac myocytes and fibroblasts have demonstrated the ability to self-organize and spontaneously contract in culture for several weeks. The presence of conduction structures, such as gap junctions, adherens junctions, Z bands, T-tubules, mitochondria, and sacroplasmic reticulum, creates electrical conduction pathways similar to that of the native heart tissue. Electrophysiological testing shows cells exhibit electrical signal similar to regular ventricular activity and in some studies sinus node-like action potentials. Stem (Progenitor) cells are defined as pluripotent cells with the capacity to divide asymmetrically (self-renewal), producing copies of itself and more committed daughter cells, which will generate a large number of mature cells. They
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