PS%208_solutions - BIOE 322/BIOS 332 Fundamentals of...

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Page 1 of 3 BIOE 322/BIOS 332 Fundamentals of Systems Physiology Spring 2008 Problem Set #8 Solutions 1. At high altitudes, the atmospheric P O2 decreases because of a decrease in atmospheric pressure. The decreased atmospheric P O2 results in a decrease in alveolar P O2 and less oxygen diffusion into lung tissue. If the person’s arterioles are especially sensitive to the decreased oxygen levels, constriction of the arterioles reduces blood flow through the lungs and the ability to oxygenate blood decreases. Such generalized hypoxemia can also be caused by certain respiratory diseases, such as emphysema and cystic fibrosis. 2. A person who cannot synthesize BPG has mild erythrocytosis. Her Hb releases less O 2 to tissues. Consequently, one would expect increased erythropoietin release from the kidneys, and increased RBC production in red bone marrow. 3. The movement of CO 2 from fetal blood into maternal blood increases CO 2 levels inside maternal RBCs. As a result, pH inside maternal RBCs decreases, the affinity of maternal Hb for O 2 decreases, and more O 2 is released (maternal O 2 -Hb curve shifts to the right). The movement of CO 2 from fetal blood into maternal blood decreases CO 2 levels inside fetal RBCs. Consequently, pH inside fetal RBCs increases, the affinity of fetal Hb for O 2 increases, and more O 2 binds to fetal Hb (fetal O 2 -Hb curve shifts to left). This shifting of the maternal and fetal O 2 -Hb curves is called the double Bohr effect. The double Bohr effect increases the delivery of O 2 from maternal blood to fetal blood because maternal Hb releases more O 2 and fetal Hb is more effective at picking up that O 2 . 4. Hyperventilation decreases blood CO 2 levels, causing an increase in blood pH. Breathing into a paper bag corrects for the effects of hyperventilation because the person re-breathes air that has a higher concentration of CO 2 . The result is an increase in CO 2 in the body. Consequently, pH decreases toward normal levels. Holding one’s breath increases blood CO 2 levels, decreasing blood pH. 5.
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This note was uploaded on 04/26/2008 for the course BIOE 332 taught by Professor Suh during the Spring '08 term at Rice.

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PS%208_solutions - BIOE 322/BIOS 332 Fundamentals of...

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