Animal-notes - Animal Subjects Research Ethical Care and...

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Animal Subjects Research Ethical Care and Use of Animals Guy Mulder, DVM University Laboratory Animal Resources, UCI
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Overview Discussion topics: Introduction to Animal Use Ethics of using animals in research Animal Welfare Laws and Regulations Institutional Animal Care and Use Committee Protocol to use animals Hazards of working with animals
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Animal Use in Research Animals have played (and continue to play) a heroic and vitally important role in medical research Medical progress - for both human and animal health - requires animal research.
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Pre-1900s--Rabies, Smallpox 1900s-Cardiac catheterization 1920s-Insulin therapy--Diabetes 1940s-Antibiotics, Diptheria prevention 1950s-Polio, Cardiac Pacemakers 1960s-Rubella prevention 1970s-Measles prevention, Leprosy treatment
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1980s-Monoclonal antibodies, Organ transplant advances 1990s-Laparoscopic surgery, Gene therapy, AIDS research, Cancer chemotherapy Future-- Xenotransplantation Cloning?
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Animals Used in Research, Testing and Teaching (USA) 70,082 dogs 22,755 cats 49,382 non-human primates 256,193 guinea pigs 167,231 hamsters 267,351 rabbits 26,236 sheep 60,253 pigs 75,169 farm animals 242,251 other animals Total = 1,236,903 (USDA annual report, 2001)
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Mice and Rats 20-50 million used annually in research 300-400 million produced commercially Pet trade Reptile food Etc. -Lib. Of Congress, 8/00
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Why Use Animals in Research Ethical Arguments Nuremberg Code of Ethics in Medical Research Declaration of Helsinki
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Why Use Animals . .. The Nuremberg Code 1. “…voluntary consent of human subject…” 2. “…should yield fruitful results for the good of society, unprocurable by other means…” 3. “. .. be designed and based on results of animal experimentation and a knowledge of the natural history of the disease…”
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Why Use Animals . .. Declaration of Helsinki “Medical research involving human subjects…generally accepted scientific principles…and, where appropriate, animal experimentation .” -World Health Organization, 1964
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Ethical Positions Numerous, including. .. Divinely-granted dominion (ie: The Bible ) Reverence for life Animal rights Utilitarianism (ie: animal welfare) stewardship vs. scientific and societal benefit basis for contemporary animal welfare regulations
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Animal Rights Animal Rights Animals and man share equal rights--both are moral agents “personhood” for animals All sentient beings deserve equal moral consideration Animal-based research is never justified, nor is pet ownership, food or fiber production, etc.
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Notable Quotes Even if animal research resulted in a cure for AIDS, “we’d be against it.” “A rat is a pig is a dog is a boy. They’re all animals.” Ingrid Newkirk, PETA “The life of an ant and my child should be granted equal consideration.” M. Fox, HSUS
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Fact vs. Myth
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This note was uploaded on 04/26/2008 for the course BIO SCI 194s taught by Professor Melitz during the Spring '07 term at UC Irvine.

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Animal-notes - Animal Subjects Research Ethical Care and...

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