Here is a view into the nonnucleotide inhibitor

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Unformatted text preview: re is a view into the nonnucleotide inhibitor binding site. This binding site is near the active site consisting of the catalytic residues Asp 110, Asp 185, Asp 186, but distinct from it. When the Dipyridodiazepinone Nevirapine nonnucleoside inhibitor (seen in red and sticks) binds, it repositions the aspartyl residues inactivating the polymerase. The residues that interact with the inhibitor are shown in ball and stick representation. Images by Karen Ellis, School of Chemistry and Biochemistry, Georgia Tech, 1998. Ca...
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This note was uploaded on 04/26/2008 for the course CHEM 51A taught by Professor Sangodkar during the Fall '07 term at UC Irvine.

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