WS1-W08-review - can assume that A and B are very similar...

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Week 1 Chem 51B - Jarvo Worksheet 1 – REVIEW of 51A 1. Consider the addition of sodium methoxide to the following epoxide: HO NaOMe ! G = -20 kcal/mol + A B HO O OMe OMe a. Is sodium methoxide an acid or a base? A strong or weak nucleophile? b. Draw a mechanism for the reaction. You should have one pathway that provides product A and second pathway that provides product B . Will A or B be the major product and why? c. Draw a reaction coordinate diagram that describes the two reaction pathways. You
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Unformatted text preview: can assume that A and B are very similar in energy. Label the following: starting material product A and product B transition states () and any intermediates G A and G B (both = -20 kcal/mol) Whether the reaction is exothermic or endothermic. G A, G B a nd G 2. Assign the following compounds as having the ( R ) or ( S ) configuration. CH 3 OH CH 3 CH 3 CH 3 Cl H H 3 C H OH CH 3 CH 3 H 3 C H 3 C...
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