reaction summary - enols and enolates

reaction summary - enols and enolates - Carbonyl...

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Carbonyl α -Substitution and Condensation Reactions Enol formation O C R Alkylation H OH C R O C R H 1. Base 2. R'X O C R R' Malonic Ester Synthesis O C RO C H 2 1. Base 2. R'X O C HO C H 2 R' C O OR 3. H 3 O + , heat + CO 2 + 2 ROH O C H C H 2 R Base O C H CH Aldol Synthesis CH CH 2 R OH R A β -hydroxy aldehyde H + O C H C Aldol Dehydration C A β -hydroxy aldehyde O C H CH C OH or HO - O C RH 2 C OR' Base O C RH 2 C CH Claisen Condensation Reaction C OR' O R β -keto ester 2 2 O C H 2 C OR' Base O C H 2 C CH Dieckmann Cyclization C OR' O A cyclic β -keto ester O C H 2 C OR" O C R' C H 2 Base C O R" Michael Reaction C C C O OC
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This note was uploaded on 04/26/2008 for the course CHEM 20221 taught by Professor Loyle during the Spring '08 term at Rowan.

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