Practice_Exam3_fromF07_ans

Practice_Exam3_fromF07_ans - Molecular Genetics 382...

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Molecular Genetics 382 Practice Exam 3 ANSWER KEY Answer to added question for Ch. 12: Briefly describe how bZIP proteins interact with their DNA binding site (you may draw a rough sketch too, if you wish). What is the role of the “b” domain? What is the role of the “ZIP” domain? - Refer to Fig. 12.11a&b for a picture. The “b” (basic”) domain is responsible for contacting the DNA, while the “ZIP” domain is a dimerization domain that holds the two copies of the protein together. 1) Briefly compare and contrast the Group I and Group II self-splicing mechanisms (describe one major similarity and one major difference). i) Similarity (2 pts): - Attack by an –OH group on the 5’ splice site - No need for additional proteins (i.e. spliceosome-independent) ii) Difference (2 pts): Group II: 2’-OH from A makes intramolecular attack and forms a lariat-shaped intermediate/intron Group I: 3’-OH from GTP makes intermolecular attack - no lariat-shaped intron 2) Each of the items in list A recognizes one of the items in list B. Match each item in list A with the appropriate item in list B. (6 pts) List A: match from list B (just give letter) : 1) U1 snRNP 1) _ b (5’ splice site) _ 2) U2 snRNP 2) _
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