G Chapter 12 - Chapter12: Deletions,inversions, Deletion:

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Chapter 12: Chromosomal Rearrangements and Changes in Chromosome Number  Deletions, inversions, duplications and reciprocal translocations come by either of two events:   chromosomal breakage or aberrant recombination  Deletion: two double-stranded breaks and there is a loss of fragment between the breaks Inversion: a fragment rotates by 180 °   Deletion & Duplication: breakage of two homologous chromosomes or sister chromatids at  different locations and the ends change places before DNA brings them together for repair  Translocation: breakage of two nonhomologous chromosomes and the ends switch places before  repair and fusion Aberrant crossing over can cause four types of chromosomal rearrangement Deletion: crossing over b/w repeats of the same sequence at two locations on same chromosome  Inversion: if the repeats are in opposite orientations  Deletion & Duplication: two homologous chromosomes misalign at repeat sequences & crossover  Reciprocal translocations: crossing over at repeat sequence on two nonhomologous chromosomes Homozygote deletions are lethal/harmful depending on the size of the deletions
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