Chapter 13 - Viruses, Viroids, _ Prions - Chapter 13...

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Chapter 13 Viruses, Viroids and Prions
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1) General Characteristics a. First isolated in 1935 b. Virus (Latin: “poison”) c. Inert outside host d. Very active once inside the host e. alive by clinical def., cause infxn and disease. f. Obligatory intracellular parasite
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1) General Characteristics g. Contain either DNA or RNA, but not both. h. Have a coat protein that surrounds nucleic acids i. Multiply inside living cells i. Uses host cell’s synthesizing machinery ii. Causes synthesis of specialized structures that can transfer the viral nucleic acid to other cells
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2) Host Range a. Infection characteristics i. Host specific ii. Cell type specific b. Bacteriophage or phage, infect only bacteria c. Use of viruses to treat disease i. Phage therapy – treating bacterial infection w/ viruses ii. Oncolytic viruses – viruses which target tumor cells
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3) Viral Size a. Avg. virus is 20-1000nm b. Tiny, even for microorganisms c. [Fig. 13.1] viruses vs. bacteria
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Figure 13.1
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4) Viral Structure a. Nucleic Acid – at the core of the virus i.
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