Physostigmine [Synopsis]

Physostigmine [Synopsis] - 1: Anesth Analg. 2007...

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1: Anesth Analg. 2007 Sep;105(3):739-43. Physostigmine reverses cognitive dysfunction caused by moderate hypoxia in adult mice. Bekker A , Haile M , Gingrich K , Wenning L , Gorny A , Quartermain D , Blanck T . Department of Anesthesiology, New York University Medical Center, New York, NY BACKGROUND: Cognitive changes associated with moderate hypoxia in rodents may result from the diminished functioning of central cholinergic neurotransmission. We designed this study to examine whether treatment with physostigmine (PHY), an acetylcholinesterase inhibitor, could improve the impairment of working memory after hypoxic hypoxia. METHODS: We randomized 90 Swiss Webster, 30-35 g mice (6-8 wks) to three hypoxia groups at fraction of inspired oxygen, FiO2 = 0.10 (1. no treatment; 2. PHY 0.1 mg/kg intraperitoneally administered immediately before; or 3. after hypoxia), or to two room air groups (given either no treatment or PHY after an insult). An object recognition test was used to assess short-term memory function. The object recognition test exploits the
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This note was uploaded on 04/25/2008 for the course BIOL 100 taught by Professor Martin-morris during the Fall '07 term at University of Washington.

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