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1Recovery from nerve damageStrokeHemorrhagic (hemolytic)AneurysmThrombotic (ischemic)Blood clot, atherosclerosisTraumaClosed head injuryAcuteChronicTumorsDamage from stroke•Cell damage– Overstimulation•release of K+, glutamic acid•lack of homeostasis in cellular metabolism– Understimulation• apoptosis•diaschisis (downstream understimulation)Damage from trauma•Closed head injury– Acute•Subdural hematoma; other bleeding•Contra cuinjuries– Chronic•Dementia pugilistica•Other dementias
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2Recovery• Age– Kennard principle•Young is better (often in error, however)•Physical therapy– Usually helpful• Reorganization– Many componentsReorganization of the nervous system•Regrowth of axons– Sperry: growth along/toward chemical signals– Weiss: axoplasmic transport, growth