NeuronalRecovery - Recovery from nerve damage Stroke...

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1 Recovery from nerve damage Stroke Hemorrhagic (hemolytic) Aneurysm Thrombotic (ischemic) Blood clot, atherosclerosis Trauma Closed head injury Acute Chronic Tumors Damage from stroke Cell damage – Overstimulation release of K+, glutamic acid lack of homeostasis in cellular metabolism – Understimulation • apoptosis diaschisis (downstream understimulation) Damage from trauma Closed head injury – Acute Subdural hematoma; other bleeding Contra cu injuries – Chronic Dementia pugilistica Other dementias
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2 Recovery • Age – Kennard principle Young is better (often in error, however) Physical therapy – Usually helpful • Reorganization – Many components Reorganization of the nervous system Regrowth of axons – Sperry: growth along/toward chemical signals – Weiss: axoplasmic transport, growth
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