NeuronalRecovery - Follows myelin sheaths when possible...

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1 Recovery from nerve damage Stroke Hemorrhagic (hemolytic) Aneurysm Thrombotic (ischemic) Blood clot, atherosclerosis Trauma Closed head injury Acute Chronic Tumors Damage from stroke • Cell damage – Overstimulation • release of K+, glutamic acid • lack of homeostasis in cellular metabolism – Understimulation • apoptosis • diaschisis (downstream understimulation) Damage from trauma • Closed head injury –Acute • Subdural hematoma; other bleeding Contra cu injuries – Chronic • Dementia pugilistica • Other dementias
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2 Recovery •Age – Kennard principle • Young is better (often in error, however) • Physical therapy – Usually helpful • Reorganization – Many components Reorganization of the nervous system • Regrowth of axons – Sperry: growth along/toward chemical signals – Weiss: axoplasmic transport, growth
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Unformatted text preview: Follows myelin sheaths when possible Better in PNS; usually fails in CNS Poor guidance; often fails Glial scars Sprouting of axons Usually occurs spontaneously Merzenich experiment Similar to development Probably selective apoptosis Results in humans Not always correctly rewired 3 Other neat facts: Denervation supersensitivity Surely part of the regrowth/sprouting phenomenon Effect of catecholaminergic agonists Amphetamine, other DA agonists Better when combined with PT Effect of antagonists Haldol inhibits Conclusions Things are not easy other tissues, cells heal much better Field has carefully optimistic view Better drugs other methods...
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This note was uploaded on 02/28/2008 for the course BISC 230LXG taught by Professor Mcclure,greene during the Spring '08 term at USC.

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NeuronalRecovery - Follows myelin sheaths when possible...

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