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Unformatted text preview: • Follows myelin sheaths when possible – Better in PNS; usually fails in CNS • Poor guidance; often fails • Glial scars Sprouting of axons • Usually occurs spontaneously • Merzenich experiment • Similar to development – Probably selective apoptosis • Results in humans – Not always correctly rewired 3 Other neat facts: • Denervation supersensitivity – Surely part of the regrowth/sprouting phenomenon • Effect of catecholaminergic agonists – Amphetamine, other DA agonists – Better when combined with PT • Effect of antagonists – Haldol inhibits Conclusions • Things are not easy – other tissues, cells heal much better • Field has carefully optimistic view – Better drugs – other methods...
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- Spring '08
- Neuroscience, head injury, closed head injury, Contra cu injuries, carefully optimistic view