NeurotransmittersBB

NeurotransmittersBB - • Release of NT • Depolarization...

Info icon This preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Neurotransmitters A Chemistry Primer • Elements • Atoms Covalent bonds • Compounds – Valence (C = 4, O = 2, N = 3, H = 1) Organic chemistry • Biochemistry Biochemistry • Enzymes – Substrates, products – Complementary fit Reaction pathways – Many reactions, each with its enzyme – Example: synthesis of Dopamine Molecular biology • DNA RNA protein One gene – one protein Proteins are linear polymers of amino acids. They are structural: receptors; enzymes. Proteins give us all our physical traits
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
2 Neurotransmitters The “classic eight”: GABA nor -epinephrine (NE) Epinephrine (Epi) Acetylcholine (Ach) Dopamine Histamine Serotonin Glutamic acid And yet more… • Peptides: many; potentially very many • Gases: NO, possibly others Some guiding thoughts: One neuron, one neurotransmitter: – Older concept, now broadened: One neuron, small set of NTs (often 2) Same set of NTs at all axons of a single cell May have different postsynaptic functions So how does it all work?
Image of page 2
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: • Release of NT • Depolarization of post-synaptic cell • Accumulation of stimuli – Temporal summation – Spatial summation Summation of impulses • Spatial summation • Temporal summation • Inhibition vs. activation • Sherrington’s flickering constellation 3 Hormones and Glands • Exocrine glands – To outside (or into the gut) • Endocrine glands – into blood • Hormones and neurotransmitters – May be (often are) the same molecule – Differ in distance, time, volume covered Here are a few of them (of, probably, hundreds) 4 Synthesis of neurotransmitters • Always use pathways , from other biochemicals in the body • Each step is catalyzed by an enzyme, which is specific for that step 5 Pharmacology of synapses • Most psychoactive drugs act at the synapse. • Agonists mimic the neurotransmitter. • Antagonists inhibit the stimulation. • Either may be structurally similar to the neurotransmitter, but need not be so....
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern