NeurotransmittersBB

NeurotransmittersBB - • Release of NT • Depolarization...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Neurotransmitters A Chemistry Primer • Elements •A toms • Covalent bonds • Compounds – Valence (C = 4, O = 2, N = 3, H = 1) • Organic chemistry • Biochemistry Biochemistry • Enzymes – Substrates, products – Complementary fit • Reaction pathways – Many reactions, each with its enzyme – Example: synthesis of Dopamine Molecular biology • DNA RNA protein • One gene – one protein • Proteins are linear polymers of amino acids. • They are structural: receptors; enzymes.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Neurotransmitters • The “classic eight”: GABA nor -epinephrine (NE) Epinephrine (Epi) Acetylcholine (Ach) Dopamine Histamine Serotonin Glutamic acid And yet more… • Peptides: many; potentially very many • Gases: NO, possibly others Some guiding thoughts: • One neuron, one neurotransmitter: – Older concept, now broadened: One neuron, small set of NTs (often 2) • Same set of NTs at all axons of a single cell • May have different postsynaptic functions So how does it all work?
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 4
Background image of page 5
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: • Release of NT • Depolarization of post-synaptic cell • Accumulation of stimuli – Temporal summation – Spatial summation Summation of impulses • Spatial summation • Temporal summation • Inhibition vs. activation • Sherrington’s flickering constellation 3 Hormones and Glands • Exocrine glands – To outside (or into the gut) • Endocrine glands – into blood • Hormones and neurotransmitters – May be (often are) the same molecule – Differ in distance, time, volume covered Here are a few of them (of, probably, hundreds) 4 Synthesis of neurotransmitters • Always use pathways , from other biochemicals in the body • Each step is catalyzed by an enzyme, which is specific for that step 5 Pharmacology of synapses • Most psychoactive drugs act at the synapse. • Agonists mimic the neurotransmitter. • Antagonists inhibit the stimulation. • Either may be structurally similar to the neurotransmitter, but need not be so....
View Full Document

This note was uploaded on 02/28/2008 for the course BISC 230LXG taught by Professor Mcclure,greene during the Spring '08 term at USC.

Page1 / 5

NeurotransmittersBB - • Release of NT • Depolarization...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online