extra slides lecture 5

extra slides lecture 5 - Protein Functions...

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Protein Functions Catalysis (metabolism, macromolecule synthesis, modification of protein structure/function). DNA binding/regulation (DNA compaction, replication, transcription, recombination, etc.). Structural (cell structure, scaffolds for enzymes, etc.) Signaling (hormones, intracellular signal transduction). Recognition (cell-cell interactions, immune response). Others
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Covalent modification of amino acid side chains such as phosphorylation and acetylation can act as a “switch” (on, off, alter binding properties, target for degradation, etc.). This may result in an allosteric change in the protein. Alternatively, the modification may directly affect ligand binding or cooperative interactions. Proteolysis eliminates proteins by degradation (may be tightly regulated or coupled to other activities). Ubiquitin is a small protein (7 kDa) that may be covalently linked to lysine, targeting the protein for rapid degradation. Glycosylation
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extra slides lecture 5 - Protein Functions...

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