Lecture Week 4 - 1

Lecture Week 4 - 1 - This week (Week Four): Uppers (Cocaine...

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Unformatted text preview: This week (Week Four): Uppers (Cocaine and Methamphetamine) Downers (Sedatives/Hypnotics, Benzodiazepines, Barbiturates, and Inhalants) Objectives Discuss the history of cocaine and amphetamine use and how their rates of use are related. Describe how cocaine hydrochloride and crack cocaine are processed from coca. Describe early psychiatric uses of cocaine and its current use for local anesthetic. Objectives (cont.) Explain the concerns regarding discrepancies in federal sentencing requirements for crack vs. powder cocaine. Compare and contrast route of administration and mechanism of action for cocaine and amphetamine. Discuss the dependence potential for cocaine and amphetamine. Compare and contrast supply sources for illicit cocaine and amphetamine. (cont.) Compare the chemical structure of amphetamine to the catecholamine neurotransmitter and the ephedrine. Discuss medical uses and names of new stimulant drugs. Compare/contrast acute and chronic toxicity concerns related to cocaine and amphetamines. (cont.) Give several examples of depressant drugs and describe the general set of behavioral effects common among them. Understand how concerns about barbiturate use led to acceptance of newer classes of sedative-hypnotics. Describe how the time of onset of a depressant drug relates to abuse potential and how duration of action relates to risk of withdrawal symptoms. Describe mechanisms of action for barbiturates and benzodiazepines. (cont.) Explain why it is not recommended that people use sleeping pills for more than a few days in a row. Describe several types of substances that are abused as inhalants Describe GHBs typical dose range and behavioral effects, as well as its effects when combined with alcohol. Lets start with cocaine Has been around since 5000 B.C. The Incas in Peru and Native cultures in Bolivia cultivated the plant Was known to reduce hunger, thirst and fatigue Grows well in the ideal high, wet environment of the Andes mountains Not your average COKE Native cultures chewed coca leavesmuch weaker than the cocaine of today You have to do a lot to it to get it to be what it is on the streets today. (Link to Cocaine Factory video shown in class) http://www.youtube.com/watch?v=kLGrPy1yXuc It was always valuable Just not always for money. The Incas used it as a ceremonial drug Used to increase strength and endurance Eventually used as money in trade for gold and silver Enter Angelo Mariani French chemist Exploited coca extract in many forms lozenges, teas, wine, etc. Coca Wine won him the accolades of the Pope for creating a drink that lifted the spirit, freed people from fatigue and gave them a generally good feeling. What was this AMAZING drink?...
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Lecture Week 4 - 1 - This week (Week Four): Uppers (Cocaine...

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