February 14, 2008 453

- Soc Work 453 Uppers and Downers Amphetamines(Uppers Absorption and Elimination o Like cocaine amphetamines are ingested orally nasally

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February 14, 2008 Soc. Work 453 “Uppers and Downers” Amphetamines (Uppers) Absorption and Elimination o Like cocaine, amphetamines are ingested orally, nasally, intravenously, and through smoking o Peak effect varies by route of ingestion from five minutes to one and half hours o Half life is 10-12 hours o Total elimination occurs within two days of last dose Tachyphylaxis o Rapid tolerance o Primary action is through displacement of the monoamine transmitters from their storage sites-subsequent doses may not release as much (less effect from the same dose) Next rush won’t be as high or great No drugs are all EVIL o Used to be used for depression but the mood elevation was short and mood often dropped below pre-dose level o Weight control/loss (minimally effective) o Narcolepsy (now treated with Provigil modafinil) o Hyperactive Children o Performance enhancement (mental/physical) ADHD and Stimulants o Some studies indicated that the disorder is associated with prefrontal cortex deficits o Amphetamines and methylphenidate (Ritalin) incrase brain catecholamine activity, which makes sense in the above theory o There is no accepted theory, however All drugs have concerns o Acute Toxicity Complex decision making can be impaired Paranoia and suspiciousness Increase propensity for violence??? Formication – the feeling or sensation that you have bugs crawling on your skin o Chronic Toxicity Paranoid psychosis (from dopaminergic stimulation in the mesolimbic system) Height and weight suppression (can be regained during a med vacation) o Dependence Potential Used to think you couldn’t’ get addicted because, like cocaine, there is no documented physical withdrawal that is physically dangerous or uncomfortable In reality it is analogous to cocaine: Lethargy Craving Depressed mood Downers and Inhalants Depressants and Inhalants o All ‘downers” create decreased neural activity o Known as downers, depressants, sedatives, Downers = central nervous system depressant
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This note was uploaded on 04/28/2008 for the course SOC WK 453 taught by Professor Mosher-garvey during the Spring '08 term at Wisconsin.

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- Soc Work 453 Uppers and Downers Amphetamines(Uppers Absorption and Elimination o Like cocaine amphetamines are ingested orally nasally

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