chem 3b final project

chem 3b final project - Chem3B Special Project Symthesis of...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Chem3B Special Project Symthesis of Coumarins by Ring-Closing Metathesis Introduction In Synthesis of coumarins by ring-closing metathesis , Professor F. Dean Toste, along with Arnab K. Chatterjee, Steven D. Goldberg, and Robert H. Grubbs, investigates olefin ring closing metathesis. Olefin metathesis is an organic reaction involving the redistribution of olefinic (alkene) bonds. The paper further explains the discovery that this mechanism leads to a general method for the synthesis of coumarins. Olefin metathesis is widely used in polymer synthesis by ring-opening metathesis polyermizations and step-growth polymerizations. The purpose of this paper is to further investigate the effect of olefin ring-closing metathesis for the production of coumarins through higher activity catalysts which promote intramolecular reactions between two-electron deficient olefins. This method allows for a variety of couramins substituted at both the 3- and 4- positions. Discussion This paper focuses on the synthesis of simple and important highly functionalized products from applying ring-closing metathesis (RCM). The discussion is driven by the availability of many catalysts of varying activities. The paper describes using these catalysts specifically; ruthenium-imidazoylidene catalyst as catalyst 1 and bis-phosphine catalyst as
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/28/2008 for the course CHEM 3b taught by Professor Pederson during the Fall '08 term at Berkeley.

Page1 / 3

chem 3b final project - Chem3B Special Project Symthesis of...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online