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Neural basis of Memory

Neural basis of Memory - Neural basis of Memory Hippocampus...

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Neural basis of Memory Hippocampus role in memory; difference from other regions? A) Object memory B) Spatial memory C) Theories of hippocampal function D) Structures involved Neural Basis of Object Memory: 1) Animal studies of MTL functions i) Research involves monkeys *Delayed Non-matching To Samples Test (With lesion in bilateral MTL) Given variable time, how well will monkey remember item that does not belong? Results: Control monkeys ( without lesion 90% accuracy with delay of ~1 min. Experimental monkeys ° Normal performance with delay under 1 min °Longer delays= poor performance Rats : Same experiment is done with two sides of a cage with food under novel item
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Results : Control : Normal rats perform well with delays under 1 min Experimental Rats: SEVERE DEFICITS at long delays 2) Which part of MTL is important in object recognition? Previous lesions were NOT clean ° Rhinal cortex (ento/perirhinal cortex) were often damaged along w amygdala and hippocampus (reduces performance at delays
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