Quiz _3-06a - Remember that males are hemizygous for...

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Name _______________________ Biology 392 November 7, 2006 Quiz #3 - 10 pts TAKE HOME: DUE Tuesday November 14, 2006 1. A rare form of polydactyly (extra fingers and toes) in humans is due to an X-linked recessive gene, whose chromosomal location is unknown. Suppose a geneticist studies the family whose pedigree is shown below. She isolates DNA from each member of the family, cuts the DNA with a restriction enzyme, separates the fragments by electrophoresis on an agarose gel, and transfers the DNA to nitrocellulose by Southern blotting. She then hybridizes the nitrocellulose with a cloned DNA sequence that comes from the X chromosome. The pattern of bands is shown below each person on the pedigree as follows: a. For each person in the pedigree, give his or her genotype for the RFLPs revealed by the probe.
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Unformatted text preview: Remember that males are hemizygous for X-linked genes, and females can be homozygous or heterozygous). I1 RF 3 y II4 RF 2 y I2 RF 1 RF 2 II5 RF 1 RF 3 II1 RF 1 y II2 RF 2 y II6 RF 2 y II3 RF 2 RF 3 II7 RF 1 y b. Is there evidence for close linkage between the probe sequence and the X-linked gene for polydactyly? Explain your reasoning. Yes, there is evidence that there is close linkage because the daughters and the mothers share the same probe sequence and RF 2 is a carrier. c. How many daughters in the pedigree are likely to be carriers of X-linked polydactyly? Explain your reasoning. 1 daughter is likely to be a carrier because the first daughter has the RF 2 gene and the other daughter does not have that gene. Name _______________________ Biology 392 November 7, 2006 Quiz #3 - 10 pts...
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This note was uploaded on 04/29/2008 for the course BIO 392 taught by Professor Tomkiel during the Fall '06 term at UNC Greensboro.

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Quiz _3-06a - Remember that males are hemizygous for...

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