Practice%20Problems%20No_6

Practice%20Problems%20No_6 - turn derived from,...

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turn derived from, respectively, ADP, GDP, and CDP in reactions catalyzed by the ribonucleotide reductase. The ribonucleotide reductase catalyzes the 2’-OH group removal on its ribonucleoside diphosphate substrates (i.e. ADP, GDP, CDP, also UDP) to form the 2’- deoxyribonucleoside diphosphate products (i.e. dADP, dGDP, dCDP, and dUDP). 5. After the catalytic conversion of a ribonucleoside diphosphate (NDP: the generic term, N stands for nucleoside) to a 2’-deoxyribonucleoside diphosphate, a disulfide bond is formed between the two SH groups from two Cys residues in the active site of ribonucleotide reductase. This disulfide bond has to be reduced back to the original free SH groups in the active site. How is this reduction accomplished? Key: The reducing equivalent NADPH donates its two electrons that are ultimately transferred (mediated by proteins thioredoxin reductase and thioredoxin) onto the disulfide bond formed in the active site of ribonucleotide reductase, reducing it to the original free SH groups. In specific, the two electrons of NADPH are transferred onto the FAD prosthetic group of thioredoxin
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This note was uploaded on 04/29/2008 for the course 3150 402 taught by Professor Zheng during the Spring '08 term at The University of Akron.

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Practice%20Problems%20No_6 - turn derived from,...

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