Practice%20Problems%20No_3 - Key points i the proton flow...

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Key points: i) the proton flow from the P side (positive side or intermembrane space) to the N side (negative side or matrix side) through the F 0 part of ATP synthase drives the rotation of C 10 (assembly made from 10 copies of subunit C). ii) the rotation of C 10 brings about the rotation of the ε and r subunits of the F 1 part of ATP synthase. The three αβ protomers of the F 1 part do not rotate. iii) the rotation of the r subunit is not smooth, but has three discrete jumps of 120° each turn. iv) The rotation of the r subunit brings about conformational changes of the three αβ protomers of the F 1 part of ATP synthase. The unique rotatory movement of the r subunit is consistent with the simultaneous conformational changes of the three αβ protomers because they are arranged 120° relative to each other around the r subunit. v) There are three conformational states for each αβ protomer, i.e. O: open (very low affinity for ligands and catalytically inactive); L: loosely binding ligands, catalytically inactive; T: binding ligands tightly, catalytically active.
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