D103 lect17C HL

D103 lect17C HL - Compartmentalization of signaling...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
Page 1 Compartmentalization of signaling machinery facilitates speed and precision of signaling short-term (transient) assembly of signaling components
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Page 2 Signaling proteins are composed of functional ‘modules’
Background image of page 2
Page 3 Signaling proteins are composed of functional ‘modules’
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Page 4 A co-incidence detector helps to make signaling robust Integration of independent signals enhances specificity of response.
Background image of page 4
Page 5 Summary of Lecture 16 Cells can respond to a wide range of_________ . Most stimuli ______ penetrate cell membrane and require a plasma membrane localized_________. Components of a signaling pathway involve_________ ,_________, __________and _________. Signals can act over ______or _____distances and can be _______or _______. Combinations of multiple signals, multiple receptors and multiple modulators permits enormous numbers of independent signaling mechanisms. There are ______ major classes of cell surface receptors. Activation of the receptors by ligands occurs in different ways . Second messengers play an important role in signal amplification. •A signal transduction pathway can contain a variety of components , each with a specific function. Addition or removal of a phosphate group , or hydrolysis of a guanosine triphosphate nucleotide are cellular________ that are commonly used to regulate signal transduction. Different types of functional modules are shared by many signaling proteins - L e g o !. Defective signaling can lead to problems in development or in adult homeostasis .
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Page 6 Lecture 17 – Signaling II Today’s Topics Regulation of Signaling Second messengers Recommended reading: Chapter 15, p893-917
Background image of page 6
Page 7 stimulus receptor transduction effector feedback may occur at any step negative feedback is a common method of providing robust regulation of a signaling pathway.
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 27

D103 lect17C HL - Compartmentalization of signaling...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online