lec13_vessic golgi b-post

lec13_vessic golgi b-post - Lecture#13 Vesicular Traffic...

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Copyright © 2009, Dr. Salme Taagepera,  PhD. All rights reserved. Lecture #13: Vesicular Traffic –  Late Secretory Pathway and Endocytosis
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Copyright © 2009, Dr. Salme Taagepera,  PhD. All rights reserved. Lecture #13: Vesicular Transport –  Late Secretory Pathway and Endocytosis KEY CONCEPTS : As cargo proteins move from the  cis  to  trans  face of the  Golgi , their oligosaccharide chains are modified by Golgi- resident enzymes. The trans-Golgi Network  is a major branch point in the  secretory (exocytic) pathway :  different transport vesicles  carry proteins to the surface of the cell or to  lysosomes . The  endocytic pathway  delivers ligands (e.g., LDL  particles) to lysosomes, where they are degraded.
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Copyright © 2009, Dr. Salme Taagepera,  PhD. All rights reserved. Lec. #13:  Late secretory pathway and endocytosis Modification of proteins in Golgi What are the options of a protein in the TGN? Resident TGN proteins remain in Golgi Constitutive secretion Regulated secretion Sort to lysosomes V. Endocytosis EXAMPLE : Low Density Lipoprotein (LDL)
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Copyright © 2009, Dr. Salme Taagepera,  PhD. All rights reserved. Overview of the secretory (exocytic) and endocytic pathways of protein sorting Options for proteins in the TGN: *     Resident TGN proteins remain  in Golgi Constitutive secretion Regulated secretion Sort to lysosomes Early  Sec. Path Late
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Copyright © 2009, Dr. Salme Taagepera,  PhD. All rights reserved. Golgi apparatus consists of stacked cisternae Do the Golgi cisternae  differ functionally?
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Copyright © 2009, Dr. Salme Taagepera,  PhD. All rights reserved. Histochemical stain showing the biochemical compartmentalization of the Golgi A. Unstained B.-D. Stained for enzymes  typically found in  B. Cis-Golgi C. Trans-Golgi D. Trans-Golgi *Data shows that various Golgi  cisternae contain specific  enzymes for specific tasks.
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Copyright © 2009, Dr. Salme Taagepera,  PhD. All rights reserved. Examples of the functional compartmentalization of the Golgi Preexisting sugars (N-linked) can be modified in Golgi New sugars can be added in an O-linked fashion NOTE: Data shows that processing occurs in a spatial as well as a biochemical sequence.
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Copyright © 2009, Dr. Salme Taagepera,  PhD. All rights reserved. Two possible models explaining the organization of the Golgi Apparatus and the transport of proteins from one cisternae to the next How does the Golgi achieve and maintain its polarized structure?
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lec13_vessic golgi b-post - Lecture#13 Vesicular Traffic...

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