D103 lect16 HL

D103 lect16 HL - Bio Sci 103 - Cell Biology lectures 16 -...

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Page 1 Lecturer - Dr. Lan Huang  - lanhuang@uci.edu - Office Hours:  Tuesday, 9:30-10:30 am; Thursday 12:30- 1:30 pm  2120 BioSci III Please check e-mail and web-site for announcements Lecture handouts (Powerpoint and PDF files) will be posted on web site before each  lecture. See course web site at EEE ( http://eee.uci.edu/09w/054 00 ) Emphasis will be on  general principles . PBLs, iclicker questions and homework will be used to help the understanding of basic  concepts. Primary sources of information are lectures and lecture notes. Text book is intended for use  as secondary, or cross-reference. Final exam is non-cumulative, (m/c and short-answer).  All questions will pertain to material covered in class. If confused about a subject, please look in the book for clarification. Otherwise, please seek  help from TA or come to office hours. Bio Sci 103 - Cell Biology  lectures 16 - 29
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Page 2 Lecture 16 –  Signaling  I Today’s Topics Introduction to cell communication    Basic concept   Stimuli   Signaling apparatus What is signaling and why is it needed? How are the signals transduced?  How are the signals distributed? How are the signals regulated? Recommended Reading – MBOC 5e:  Chapter 15 p879-903.
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Page 3 What is signaling and why is it needed ? The  plasma membrane   isolates  a  cell  from  its environment . Cells  require a method  to  sense their environment . Signaling  allows a cell to  receive information  from  its environment  and to  respond to the signal .
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Page 4 Signaling throughout Evolution • Bacteria - Sense nutrients • Chemotaxis  - Quorum sensing • Yeast - Pheromone signaling for haploid yeast mating • Multicellular Organisms   Many signaling pathways (e.g. G proteins, channels, kinases) Every  metazoan organism  uses  similar types of signaling  that evolved from  early primitive  multi-cellular organisms .
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Page 5  Achondroplasia - short-limbed dwarfism in humans The result of  abnormal signaling !
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Page 6 Why is signaling necessary? Cells need to sense and respond to their environment for their 
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D103 lect16 HL - Bio Sci 103 - Cell Biology lectures 16 -...

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