D103 lect16C HL

D103 lect16C HL - Bio Sci 103 Cell Biology lectures 16 29...

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Page 1 Lecturer - Dr. Lan Huang - [email protected] - Office Hours: Tuesday, 9:30-10:30 am; Thursday 12:30- 1:30 pm 2120 BioSci III Please check e-mail and web-site for announcements Lecture handouts (Powerpoint and PDF files) will be posted on web site before each lecture. See course web site at EEE ( http://eee.uci.edu/09w/054 00 ) Emphasis will be on general principles . PBLs, iclicker questions and homework will be used to help the understanding of basic concepts. Primary sources of information are lectures and lecture notes. Text book is intended for use as secondary, or cross-reference. Final exam is non-cumulative, (m/c and short-answer). All questions will pertain to material covered in class. If confused about a subject, please look in the book for clarification. Otherwise, please seek help from TA or come to office hours. Bio Sci 103 - Cell Biology lectures 16 - 29
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Page 2 Lecture 16 – Signaling I Today’s Topics Introduction to cell communication Basic concept Stimuli Signaling apparatus What is signaling and why is it needed? How are the signals transduced? How are the signals distributed? How are the signals regulated? Recommended Reading – MBOC 5e: Chapter 15 p879-903.
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Page 3 What is signaling and why is it needed ? The plasma membrane isolates a cell from its environment . Cells require a method to sense their environment . Signaling allows a cell to receive information from its environment and to respond to the signal .
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Page 4 Signaling throughout Evolution •Bacteria -Sense ±nutr ients • Chemotaxis -Quorum ±sens ing •Yeast - Pheromone signaling for haploid yeast mating • Multicellular Organisms Many signaling pathways (e.g. G proteins, channels, kinases) Every metazoan organism uses similar types of signaling that evolved from early primitive multi-cellular organisms .
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Page 5 Achondroplasia - short-limbed dwarfism in humans The result of abnormal signaling !
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Page 6 Why is signaling necessary?
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D103 lect16C HL - Bio Sci 103 Cell Biology lectures 16 29...

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