D103 LH lect17C

D103 LH lect17C - of signaling machinery facilitates speed...

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Page 1 Compartmentalization of  signaling machinery facilitates speed and precision  of signaling short-term  (transient) assembly of signaling components
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Page 2 Signaling proteins are composed of functional ‘modules’  
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Page 3 Signaling proteins are composed of functional ‘modules’  
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Page 4 co-incidence detector  helps to make signaling robust Integration of independent signals enhances specificity of response.
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Page 5 Summary of Lecture 16 Cells can respond to a  wide range of_________ . Most stimuli ______ penetrate cell membrane  and require a plasma membrane  localized_________. Components of a signaling pathway involve_________ ,_________, __________and  _________. Signals can act over ______or _____distances and can be _______or _______. Combinations of multiple signals, multiple receptors and multiple modulators permits  enormous numbers  of independent signaling mechanisms. There are ______ major classes  of cell surface receptors. Activation  of the receptors by ligands occurs in  different ways . Second messengers  play an important role in signal amplification. signal transduction pathway  can contain a  variety  of  components , each with a  specific function. Addition or removal of a  phosphate group , or hydrolysis of a  guanosine triphosphate   nucleotide are  cellular________  that are commonly used to regulate signal transduction. Different types of functional modules are shared by many signaling proteins -  L e g o  !.  Defective signaling  can lead to  problems  in  development  or in  adult homeostasis .
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Page 6 Lecture 17 –  Signaling  II Today’s Topics Regulation of Signaling Second messengers Recommended reading: Chapter 15, p893-917
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Page 7 stimulus receptor transduction effector feedback may  occur at any  step  negative  feedback is a common method of providing robust 
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This note was uploaded on 02/21/2009 for the course BIOL 05400 taught by Professor Taagepera,s during the Spring '09 term at UC Irvine.

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D103 LH lect17C - of signaling machinery facilitates speed...

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