Lecture4 - Lecture 4 1/12/09 Background reading: Garrett...

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Lecture 4 1/12/09 Outline Amino acids with positively charged R groups Amino acids with negatively charged R groups Nonprotein amino acids Chemical reactivity of amino acids Peptide bond formation Background reading: Garrett and Grisham: Chapter 4: Pages 86 - 103 Assignment: Segel Page 93: Problems 48 and 49
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Amino acids with positively charged R groups Lys K Arg R His H {Students: Please note that the letter code for Arginine is corrected in this slide to the letter R. There is a mistake in this code in the slide in the previous lecture.) Guanidinium group Imidazole group
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H H 2 N H 2 N NH pK a1 = 2.2 pK a2 = 9.0 pK a3 = 12.5 pH NaOH 1 2 3 0 If began titration with .1 mmole amino acid in Fully protonated form, would require .3 mmole Base to titrate it to the totally unprotonated form. +2 +1 +0 -1
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Amino acids with negatively charged R groups Asp D Glu E
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Nonprotein amino acids There are about 150 other amino acids that are not found in proteins. Examples:
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Lecture4 - Lecture 4 1/12/09 Background reading: Garrett...

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