Lecture 13 - Lecture 13 Note Dr Hilt will begin lecturing...

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Lecture 13 2/6/09 Outline: Origin of protein diversity Intragenic mutation Gene duplication Segment shuffling Fibrous proteins Collagen Proteins with coiled-coil framework Post-translational modifications Note: Dr. Hilt will begin lecturing in this course on Monday.
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Origin of protein diversity Analysis of human genome shows about 25,000 genes as compared to prokaryotic cells which have about 1,000 – 5,000 genes. Most of our genes probably arose during evolution from preexisting genes. There are several ways in which this can occur: Such mutations account for the differences in amino acid sequences of particular proteins during the course of evolution. As we saw with cytochrome c, the sequences can be used similar to phylogenetic traits to predict evolutionary pathways.
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These genes within a single genome can subsequently diverge in function, and whole families of such genes can arise. Over 500 different protein families have been identified to be encoded by the human genome. These families include: Oxygen-binding proteins: myoglobin and hemoglobin are among members of this family. The serine proteases: this is a large family of proteases with similar catalytic mechasnisms. It includes trypsin, chymotrypsin, elastase and several enzyme involved in blood clotting.
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This note was uploaded on 02/21/2009 for the course BIS BIS102 taught by Professor Hilt during the Winter '08 term at UC Davis.

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Lecture 13 - Lecture 13 Note Dr Hilt will begin lecturing...

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