March 3 - Nutritional Functionality in Foods March 3 Is this the right model Diseases are defined by specific pathologic criteria DIAGNOSTICS

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Nutritional Functionality in Foods March 3
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Is this the right model? Diseases are defined by specific pathologic criteria DIAGNOSTICS Determine differences between diseased and healthy TARGETS Discover molecules that act on targets as therapeutic interventions DRUGS Assume freedom from disease ?
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Nutrition must be Integrative because Healthy means getting everything right Solving one problem may create dozens more! To improve health You must have a view of the entire web
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Pursuing One disease goal to the neglect of others In a healthy population, does pursuing one disease (CVD) promote another (diabetes) in a subset of the population
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And We do not want to be the same!!!! Sports Illustrated 2002 We are not all the same!
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Challenges to Nutrition for Health Integrative: Preventing disease in healthy populations means improving all aspects of risk Personal: Disease risk and response to diet is not the same in all individuals Compliance: Food is one of life’s great personal delights
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What is Missing? Self Knowledge of Health If genes, age, lifestyle, diet, etc. are all important to health How do we know what our health status is? Strategies for Human Diets Studies of isolated food ingredients and food products are largely irrelevant Health is dependent on overall diet We need scientific models of optimal diets
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How are we Different? Phenotype = Genotype + Environment + Genotype x Environment <birth now
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Genetic Variation in normal humans -250 (G/A) -514 (C/T) -710 (T/C) -763 (A/G) Allele frequencies –514 T allele Whites: 0.20 Blacks: 0.50 Native Americans: 0.40 Asians: 0.50 Four polymorphisms in the regulatory region of hepatic lipase have been now studied intensively. The –514 site influences dietary response to fat Jose Ordovas, Tufts
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TT CC CT Plasma HDL-C by LIPC Genotypes Ordovas et al. Circulation 2002;106 2315-2321 Courtesy José Ordovas
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It’s not all Genetics Individual Phenotypes are defined by multiple factors in addition to genotype
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The ‘Lance’ advantage: Intramuscular Lipid Fuel mitochondrion myofilaments IML
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This note was uploaded on 02/21/2009 for the course FST 100B taught by Professor Germain during the Winter '08 term at UC Davis.

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March 3 - Nutritional Functionality in Foods March 3 Is this the right model Diseases are defined by specific pathologic criteria DIAGNOSTICS

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