old_midterm_2-questions

old_midterm_2-questions - Bio Sci 104 MIDTERM #2 (Lecture...

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Bio Sci 104 MIDTERM #2 (Lecture 10-19) A. There are four versions of the exam with the same questions but in different order. B. All questions have equal value. 40 questions total (3 points each). C. Number of “ * ” denotes the number of correct answers (questions 1-32). You need to mark ALL correct answers to get the credit . D. It is essential that you fill out the following both on this sheet and on Scantron (bubble in your student ID properly ). Failure to do so may result in loss of some or all credit for this exam. Your name _________________________________________________ Your student ID _____________________________________________ The version of this exam: ________a ________________ ***1. Membrane receptor tyrosine kinases such as the PDGF receptors: a. Become phosphorylated upon ligand binding b. have an intracellular kinase domain c. can be inactivated by Arrestin mediated endocytosis d. have seven transmembrane domains e. function as dimers *2. Why are collagens synthesized as pro-proteins? a. to prevent formation of the triple-stranded helix until after secretion b. to prevent hydroxylation of prolines and lysines until after secretion c. to prevent formation of fibrils until after secretion d. to allow net-like rather than fiber-like collagens to form e. to allow interactions with molecular motors **3. About vision: interaction of rhodopsin with light activates a cyclic-GMP (cGMP) phosphodiesterase, which reduces the levels of cGMP, leading to a. opening of cGMP gated Na+ channels b. closure of cGMP gated Na+ channels c. hyperpolarization d. hypopolarization e. higher rate of transmitter release **4. Src tyrosine kinase family: a. are transmembrane proteins b. associate with cytokine receptors that do not possess enzymatic activities c. associate with cytokine receptors that also possess enzymatic activities d. phosphorylates and activates the Smad transcription factors e. most members contain both SH-2 and SH-3 domains **5. When the receptor tyrosine kinases PDGF receptors are activated by growth factor: a. GAP is recruited to the receptor at the cell membrane to activate Ras b. phospholipase C- β is activated to generate DAG and IP3 which in turn activates protein kinase A c. phospholipase C- γ is activated to generate DAG and IP3 which in turn activates protein kinase C d. Phosphatidyl inositol 3-kinase is activated to generate PI(3,4,5)P3 e. Phosphatidyl inositol 3-kinase is activated to generate IP3
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Bio Sci 104 *6. Interferon receptors act through a tyrosine kinase-transcription factor partnership. What are the names of members of this kinase/transcription factor family? a. FGF/c-Jun b. Src/Lck c. PKA/CREBP d. Jaks/STATs e. PKC/NF-kB ***7. Grb2 is an adaptor protein that a. associates with phosphorylated receptors through the SH2 domain on Grb2. b. attracts downstream component SOS via the SH3 domain
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This note was uploaded on 02/22/2009 for the course BIS 104 taught by Professor Scholey during the Winter '08 term at UC Davis.

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old_midterm_2-questions - Bio Sci 104 MIDTERM #2 (Lecture...

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