In class notes for December 10, 2007

In class notes for December 10, 2007 - Introduction to...

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Introduction to Biological Sciences 110a In class notes for December 10, 2007 Regulation of gene expression o Transcription Eukaryotes- Only Polymerase II There are multiple polymerases in eukaryotes, but we will only focus on polymerase 2 The polymerases do not bind directily to the poromoter, and there are TFs that will assist There are more genes to worry about (2X-10X). Much more DNA Multicellular Eukaryotes have packaging (histone core octamer, etc) For expression you must have the 10nm fiber. Brought about by coactivators and chromatin remodeling proteins. These modify the histones to destroy the reaction between the nucleosomes. Signal transduction pathway regulate activity of transcription factors. o There are receptors on the cell surface which bind to ligands, which can be hormones, neurotransmitters, light in your eye. Binding of the ligand to the receptor initiates second messengers. o
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In class notes for December 10, 2007 - Introduction to...

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