In class notes for November 2, 2007

In class notes for November 2, 2007 - Introduction to...

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Introduction to Biological Sciences 111a In class notes for November 2, 2007 Help session on Sunday at 3pm Today o Repair of DNA o Mutations of Mutagenesis Mutations are both good and bad Tautomerization o A chemical property of the bases o This can lead to DNA polymerase errors o Remember you have keto groups and amino groups attached to the aromatic rings o See A o Also see slide D and A stand for donor and acceptor, this is because rearrangement changes the hydrogen bonding o There is also a slide that shows how the hydrogen bonding will change due to rearrangement o See B o This is rare, however at some rare instances it does happen o If polymerase put the A there then the editing site most of the time will catch it because the C will have switch back to its correct form, but some times it doesn’t. o This is just a mismatch, this is a premutagenic legion. o If a mistake occurs by the polymerase it COULD turn into a mutation o ACAG→ ACAG TGTC o TGTC→ACGG TGTC (the t enol looks like a C) so this is a mismatch (premutagenic legion) o The top strand would replicate ACGG which is NOW a mutation because it TGCC is passed from one generation to the other This is called a point mutation because it is only A change in one base pair Bottom strand ACAG
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Introduction to Biological Sciences 111a In class notes for November 2, 2007 TCTC o The mutation just described is called a spontaneous mutation, meaning it occurred without an outside influence, just by the chemical instability
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In class notes for November 2, 2007 - Introduction to...

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