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In class notes for November 12, 2007

In class notes for November 12, 2007 - Introduction to...

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Unformatted text preview: Introduction to Biological Sciences 110a In class notes for November 12, 2007 • Gene expression • Transcription • Bacteria • Core polymerase o Alpha, beta, beta prime, w o Elongation o Termination • Holopolymerase o Alpha, beta, beta prime, w and o o Initiation o Sigma subunit o Provides promoter specificity • There are several different sigma subunits o Mostly σ 70 – promotes with consensus sequences presented last time o Most cells only have σ 70 however under certain conditions you lose this one and gain σ 32 . This happens when you have heat shock. o This alters the sequence the holopolymerase binds to o Turning this on and off is a way of global regulation of large sets of genes • We’ve talked about promoters, composition of polymerase molecule, and termination • SEE A • Binding is more stable than nonbinding • Some of the binding energy is used to unwind and unpair a region of DNA of about 20 bp • SEE B • NTPs diffuse in, SEE C Int roduction to Biological Sciences 110a In class notes for November 12, 2007 •...
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In class notes for November 12, 2007 - Introduction to...

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