In class notes for October 10, 2007

In class notes for October 10, 2007 - Introduction to...

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Introduction to Biological Sciences 110a In class notes for October 10, 2007 The cytoskeleton o Maintains cell structure (acts as a molecular skeleton) o Microfilaments are concentrated around the nucleus, they are also often found beneath the plasma membrane Used for movement Used to apply force Used for intracellular movement Structure and motility o Three kinds of filaments (made of protein assemblies) Microtubles Microfilaments Intermediate filaments Microtubles o The largest in diameter of the cytoskeletal filaments o They have a diameter of about 25 nm, or 250Å o They are hollow structures o The space in the middle is about 170Å across o They are made up of rows of protein subunits o Each row is called a protofilament o Most have 13 protofilaments o Each protofilament is made of rows of protein subunits o There are two types of protein subunits: Alpha tublin Beta tublin These are very similar o Alpha and Beta tublin both bind a molecule of GTP Alpha binds it irreversibly (they use it as a prosthetic group)
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Introduction to Biological Sciences 110a In class notes for October 10, 2007 Beta binds it exchangebly (it can come off or on repeatedly) and can hydrolzye and for GDP GTP regulates microtuble assembly (decides if it will be in a microtuble or floating around in the cytosol) GDP makes it shorter GTP lets it grow Look up signal recognition particle on ER. Look up vesicle coat protein assembly. GTP is involved in both of these o Microbules are structually polar They have physically different ends They are considered to have + and – ends o On the slide ??? about what end is what o A singlet microtuble is the one we have been describing
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This note was uploaded on 02/22/2009 for the course BSCI 110A taught by Professor Broadie/patton during the Fall '08 term at Vanderbilt.

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In class notes for October 10, 2007 - Introduction to...

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