In class notes for October 24, 2007

In class notes for October 24, 2007 - Introduction to...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Introduction to Biological Sciences 110a In class notes for October 24, 2007 More on checkpoints When cyclin concentration goes down, it can no longer bind CDK Cyclin concentration can be affect when you o Regulate the synthesis rate of cyclin mRNA, cyclin protein o Regulate the degradation rate o Modify cyclin Cyclin D and CDK 4 is a pair involved in the transition of the cell in the G1 to S transition, or the restriction point CDKs phosphorylate a number of target protein o One example of a target protein is a retino blastoma protein (RB protein) o E2F is a transcripition factor (allows or prevents a gene from being transcribed) o RB can no longer bind to E2F, and they separate o E2F can now enter the nucleus and either turn on genes or turn off genes Another target of the CDK is the cyclin D o The CDK can phosphorylate the cyclin o The cyclin that is phosphorylated is unstable RB is an example of a tumor suppressor protein o A tumor suppressor protein is involved in generally inhibiting cell cycle events
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/22/2009 for the course BSCI 110A taught by Professor Broadie/patton during the Fall '08 term at Vanderbilt.

Page1 / 3

In class notes for October 24, 2007 - Introduction to...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online