In class notes for October 29, 2007

In class notes for October 29, 2007 - Introduction to...

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Introduction to Biological Sciences 110a In class notes for October 29, 2007 Help sessions: Tuesday 4:10 pm, Sunday 3:00 pm Replication o See A o Conservative replication Old strands pair with old and new strands pair with new o Semiconservative replication (the one used in DNA) New strands pair with and old strands o Dispersive New strand and old strand fragements are mixed o Stahl and Mesels proved that DNA used semiconservative replication (see Figure 13.3, pg. 544) o See B o One strand is called the elongating strand (also refered to as the primer), the other is the template o Replication uses enzymatic machinery There are many proteins involved in DNA replication DNA polymerases o We will concentrate in bacteria (archaea) on polymerase III and in Eukaryotes on , δ ε These are major replicators They are very accurate, however if something does go bad they can’t deal with it. This is where the translesional or by-pass polymerases come in. (See Below) Why are these polymerases so accurate? There is a strict requirement for the standard base pair geometry o See C There is a second active site in these polymerases (refered to as
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In class notes for October 29, 2007 - Introduction to...

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