D103 LEC 5 - Lecture #5 Cytoskeleton I - General...

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Copyright © 2009, Dr. Salme Taagepera, PhD. All rights reserved. Lecture #5 Cytoskeleton I - General Principles
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Copyright © 2009, Dr. Salme Taagepera, PhD. All rights reserved. Lec #5 : Cytoskeleton - General Principles I. Cytoskeleton is dynamic! II. Types of filamentous networks III. Cytoskeletal behavior 1. Assembly from subunits into higher order structures 2. Nucleation is the rate limiting step 3. Treadmilling (mainly actin filaments) and dynamic instability (mostly microtubules) 4. Dynamics are regulated by accessory proteins subunit sequestering proteins proteins that bind alongside the filament capping proteins
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Copyright © 2009, Dr. Salme Taagepera, PhD. All rights reserved. Cytoskeleton: the skeleton of a cell Cells need a (cyto)skeleton to: create shape change shape allow movement ~ dynamic!
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Copyright © 2009, Dr. Salme Taagepera, PhD. All rights reserved. The cytoskeleton is dynamic due to its construction from monomers monomer construction - monomers very abundant - subunits are NOT covalently linked accessory proteins -regulate site and rate of filament nucleation -regulate polymerization and depolymerization
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Copyright © 2009, Dr. Salme Taagepera, PhD. All rights reserved. Lec #5 : Cytoskeleton - General Principles I. Cytoskeleton is dynamic! I. Types of filamentous networks 1. Microtubules (MT): organelle positioning, intracellular transport 2. Actin filaments (AF): cell shape, whole-cell locomotion 3. Intermediate filaments (IF): mechanical strength
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Copyright © 2009, Dr. Salme Taagepera, PhD. All rights reserved. Cells have three cytoskeletal elements Actin Intermediate filaments Microtubules icrotubules (MT): organelle positioning, intracellular transport ctin filaments (AF): cell shape, whole- cell locomotion ntermediate filaments (IF): mechanical strength
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Copyright © 2009, Dr. Salme Taagepera, PhD. All rights reserved.
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This note was uploaded on 02/21/2009 for the course BIOL 05400 taught by Professor Taagepera,s during the Spring '09 term at UC Irvine.

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D103 LEC 5 - Lecture #5 Cytoskeleton I - General...

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