lec08_IF b - Normal Mutant Cytoplasmic IF Nuclear IF...

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Lecture #9 Cytoskeleton IV – Intermediate Filaments Copyright © 2009, Dr. Salme Taagepera,PhD. All rights reserved. Normal Mutant Cytoplasmic IF Nuclear IF
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Copyright © 2009, Dr. Salme Taagepera,PhD. All rights reserved. Lec #9 : Cytoskeleton IV –IF Intermediate filaments A. Function and structure of IF Heterogenous group of proteins Impart mechanical strength to cell B. Sample IFs 1. Keratins and their role in tissue maintenance 2. Lamins and their role in nuclear organization
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Copyright © 2009, Dr. Salme Taagepera,PhD. All rights reserved. Three filamentous networks in eukaryotic cells MT: hollow tubes made of tubulin • rigid, long, straight MF/AF: helical polymers made of actin • flexible, organized into 2D networks and 3D gels IF: heterogenous group filamentous proteins • rope-like structure used to give cell mechanical strength 25 nm 10 nm 7 nm
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Copyright © 2009, Dr. Salme Taagepera,PhD. All rights reserved. Characteristics of intermediate filaments found mainly in multicellular organisms tissue specific impart physical strength to cells and tissues lateral self association no filament polarity dynamic integrated with the other cytoskeletal fibers Keratin (cytoplasm) Lamin (nucleus)
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Copyright © 2009, Dr. Salme Taagepera,PhD. All rights reserved. Comparison with actin filaments : Both usually associated with cell membranes Networks are dynamic Contrast to actin filaments : IF subunits are alpha-helical rods (not globular proteins) Very stable due to large number of lateral interactions Do not contribute to cell motility IF do not bind nucleotides IF v. Actin Filaments
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Copyright © 2009, Dr. Salme Taagepera,PhD. All rights reserved. Intermediate filaments fulfill diverse functions 70 family members with conserved tripartite secondary structure
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Copyright © 2009, Dr. Salme Taagepera,PhD. All rights reserved. Model of intermediate filament construction Intermediate filament construction→ final 10nm rope-like filament
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Copyright © 2009, Dr. Salme Taagepera,PhD. All rights reserved. DATA:
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This note was uploaded on 02/21/2009 for the course BIOL 05400 taught by Professor Taagepera,s during the Spring '09 term at UC Irvine.

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lec08_IF b - Normal Mutant Cytoplasmic IF Nuclear IF...

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