Hlth 102 SU - 5

Hlth 102 SU - 5 - 1 Hlth 102 Class 5 Factors that influence...

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1 Hlth 102 – Class 5 Factors that influence drug actions
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2 Today: Factors that influence drug actions 1. Entry of drugs into the body 2. Circulation of drugs in the body Many factors can influence the size of the effect on the  body  3. Excretion of drugs and metabolites from the body 4. Genetics
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3 1. Route of Administration - reading p111-114 Drugs must get to their receptors to act Route of administration affects drug experiences Inhalation Injection Mucosal – body cavity Oral Transdermal (skin patches)
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4 2. Within the Body Dose Potency Purity Drug interactions
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5 Dose – Response Relationship - reading p106-110 Very low dose – no effect is seen Dose threshold – an observable effect Slow increase in observable response All-or-none response  Dose response curve   a graph showing the relationship between the size of a dose  and effect(s) of the drug Can show a multitude of effects that occur at different  thresholds
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6 Dose Response Graph - Alcohol Source: course text p243 *Ataxia = staggering and the inability to walk * 1 1 2 3 4
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7 Therapeutic Index (TI) (safety ratio) Effective dose (ED 50 ) The dose at which 50% of a specified population will experience a  particular drug effect Lethal dose (LD 50 ) The dose at which 50% of a specified population will  die  from a  particular drug effect Therapeutic index (TI) = LD 50   / ED 50 10 or lower is quite hazardous
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Hlth 102 SU - 5 - 1 Hlth 102 Class 5 Factors that influence...

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