MolEvolHW key - Genetics Problem Set: Molecular Evolution...

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Genetics Problem Set: Molecular Evolution 1a. What two types of data/observations led to the neutral theory of molecular evolution? More 1) polymorphisms within species and 2) divergence between species, both at the nucleotide or amino acid sequence level, than could be explained by Darwinian natural selection. 1b. According to neutral theory, are the majority of new mutations neutral, deleterious or advantageous? They are deleterious. 1c. According to neutral theory, are the majority of sequence differences (fixations) between species neutral, deleterious or advantageous? They are neutral. 2. Are all synonymous mutations in coding regions neutral? Why or why not? There is very little selection on synonymous mutations, since they do not change the amino acid sequence, but some selection can be detected in the form of codon bias. Possible explanations for this selection include the fact that some codons may be translated faster, or may be more robust to mutation. 3. Are all mutations with strong functional effects found in coding regions? If not, where
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This note was uploaded on 02/23/2009 for the course ECOL 320 taught by Professor Weinert during the Fall '07 term at University of Arizona- Tucson.

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MolEvolHW key - Genetics Problem Set: Molecular Evolution...

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