2-17-09 - Outline for Chapter 6 Gene interaction 1....

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Unformatted text preview: Outline for Chapter 6 Gene interaction 1. Interactions between the alleles of a single gene - complete dominance and recessivenes - recessive mutations — wild-type allele is haplosufficient - dominant mutations — wild-type allele is haploinsufficient WP}, — incomplete dominance CO - Wominance - human ABO blood groups - sickle-cell anemia (Glu6 ——> Val6 in the B-chain of hemoglobin) HbA/HbS - anemia or normal — complete dominance - blood-cell shape — many cells slightly sickle shaped — incomplete dominance - hemoglobin — codominance _ - recessive lethal alleles 7 - yellow coat-color in mice - pleiotropic (If; 2. Interaction of genes in pathways L biog )ASLM \\ Q OJL 3W ")1 C5 > - biosynthetic pathways in Neurospora fl - one gene-one enzyme hypothesis - use of mutants to determine biochemical pathways 3. Inferring gene interactions 0 — complementation test / - single trait — two genes — 9:3 :3 :l dihybrid ratio — no gene interaction gi was/Q ‘ - Dominant epistasis (12: 3: 1) ‘ — Recessive epistasis (9: 3: 4) W M Vow N - Duplicate dominant genes (15: l) / (L - Duplicate recessive enes (9: 7) / g - Dominant and recessive interaction (13: 3) 4. Penetrance and expressivity 64— A*>A W A>AV 0K ‘ A” v / Plefo M ism +’P\O\V\ gfvfjli ...
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2-17-09 - Outline for Chapter 6 Gene interaction 1....

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