PSL 201 Lecture 2 - PSL 201 > Lecture 2 Hemostasis:...

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PSL 201 > Lecture 2 Hemostasis: stopping of bleeding from a broken blood vessel. Bleeding- broke blood vessel - + higher pressure inside then outside. 1) Vascular constriction – vasoconstriction lowers blood flow, so reduce blood loss 2) Platelet Plug - Platelets have collagen receptor ( Damage to the endothelium + subendothilium) – binds and aggregates ( using ADP) release plate factors TXA2 into lumen. The platelet plug forms actin myosin protein complex the main protein in aggregation in VWF ( Van willebrand factor) made from megakaryocyte. Prostacyclin + Nitric Oxide – released from normal blood vessel endothelium so plug doesn’t form there. 3) Blood Coagulation: Liquid Blood into solid by converting fibrinogen to fibrin. - When plasma exposed to cologne protein called prothrombin activated thrombin catalyzes Fibrinogen (large soluble) to Fibrin (Insoluble) trap RBC. Tissue Damage ( Blood traumatize tissue) Thromboplastin (Outside tissue)
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PSL 201 Lecture 2 - PSL 201 > Lecture 2 Hemostasis:...

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