PSL 201 Lecture 3 - Phagocytosis of Pathogen-Tissue damage...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
PSL 201 > Lecture 3 Bacteria- cell wall , don’t need host to live or reproduce, killed by antibiotics. Virus- Nucleic acid core, needs host to live/ reproduce, can’t be killed by antibacterial. Immune System Leukocytes - polymorphonuclear granulicytes, mononuclear agranulicytes. Lymphoid tissue- Central- Bone Marrow, Thymus (T- Cells produced) Peripheral- Defence Innate (non specific )- resist and act against foreign agents, meet the pathogen as soon as they are presented ( Always present) Adaptive (Specific Defence)- Stimulated by specific heparin or antigen. Regulated by lymphocytes Innate : physical barriers eg. Skin mucus in lungs acidity in stomach. Inflammation , killer cells, inflammation, interferon, Complement system. Inflammation: 1) Macrophage released- engulfs foreign 2) mediators released 3) Blood flow increase and chemotaxins increase (tell phagocytes where to go). 4) Bactria contained or remain 5)contained: tissue repair, remain: additional mediators released.
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Phagocytosis of Pathogen-Tissue damage + microbes Cytokines released then phagocytosis -Histamine dilates brings in clotting proteins.-Heparin so WBC doesn’t clot in capillary. -Defensive protein (opsonins) mark the mibrobe and proliferate and WBC attack the protein marked ( by dipedisis) Globular protein : Makes interferon A,B,G, Gamma (Killer Cells) made by lymphocytes attaches to infected cell prevents replication. Interferon prevents the spread of virus. A,B secreated by virus infected cell when infected release A, B which binds to healthy cells more relealient to virus. G made from active Natural killer and T cells. Killer Cells : Attack virus w/o regognizing it -perforin, part of nonspecific immune response. Complement system : 30 protein on surface of bacteria create Major attack complex. Attaches to antibodies on bacteria or carbohydrate of cell wall of bacteria. Creates a pore water seeps in and lyses the cell....
View Full Document

This note was uploaded on 02/25/2009 for the course PSL 201 taught by Professor Wojtowicz during the Spring '08 term at University of Toronto.

Ask a homework question - tutors are online