PSL 201 Lecture 7 - PSL 201 > Mavrogiannis > Renal...

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PSL 201 > Mavrogiannis > Renal Lecture 2 Filtration Driven by osmotic pressure in the golmarulus in the renal corpuscle. The filtrate represents plasma but w/o any protein. Filtrate pass through slit pores by glomulular filtration pressure. Glomulular membrane 3 layers. 1) endothelial walls of glomulular wall- fenestrae- pores in contact with blood 2) Acellular gelatinous basal membrane- collagen for strength and proteins for charge repulsion. 3) Inner layer of bowman’s capsule- Podocytes – epithelial cells form slit pores. Forces favouring movement of fluid out of the capillary Glomulular capillary hydrostatic pressure . (60 mmHg) - lowers pressure downstream higher pressure upstream. Bowmans capsule osmotic pressure (0 mmHg) – the protein surrounding the glomulurus pulls fluid out of the capillaries. Forces opposing movement of fluid out of the capillary Bowmans capsule hydrostatic pressure (15 mmHg) – Glomulular capillary osmotic pressure . (30 mmHg) - Net filtration pressure = 15 mm
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This note was uploaded on 02/25/2009 for the course PSL 201 taught by Professor Wojtowicz during the Spring '08 term at University of Toronto- Toronto.

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PSL 201 Lecture 7 - PSL 201 > Mavrogiannis > Renal...

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