ZieglerLecture8-Lipids-Mbrs-ppt1

ZieglerLecture8-Lipids-Mbrs-ppt1 - Lecture 8: Lipids and...

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Lecture 8: Lecture 8: Lipids and Membranes Lipids and Membranes BIOCHEMISTRY 100 Winter 2009 M. Ziegler
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Learning Objectives Learning Objectives 1. Terminology (explain/defne; understand use oF terms): ±uid mosaic model, lateral diFFusion (in membrane bilayer), peripheral membrane protein, integral membrane protein, passive transport, simple diFFusion, Facilitated diFFusion, active transport, primary active transport, secondary active transport 2. Draw an saturated fatty acid, given its length in shorthand form (number of C atoms; e.g., C14:0 ); no need to memorize common names/lengths. 3. Draw any unsaturated fatty acid, given its length (number of C atoms) and the positions of double bonds, e.g., C16:1( Δ 9 ) ; no need to memorize common names/lengths/positions of double bonds. 4. Draw glycerol, a triacylglycerol, and the general structure oF a glycerophospholipid. Recognize arachidonate, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, and phosphatidylglycerol. Recognize sphingosine, a ceramide, phospho- sphingolipids (sphingomyelin), and glycosphingolipids (cerebrosides and gangliosides). Recognize a general steroid structure and cholesterol. (You don ʼ t have to recognize any other specifc steroid structures.) 5. Explain the eFFect oF chainlength and the eFFect oF cis unsaturation on the packing interactions oF Fatty acid hydrophobic tails.
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Learning Objectives Learning Objectives , continued , continued 6. Describe and sketch the structure of a lipid bilayer in an aqueous environment. 7. Explain the effect on melting point, on packing interactions, and on membrane Fuidity, of a) length of fatty acid chains, and b) number of ( cis) double bonds in fatty acid chains. 8. Describe glucose transport as an example of facilitated diffusion: describe direction of glucose transport in terms of concentration of glucose outside the cell and inside the cell, and the name of the protein “facilitator”. 9. Give an example of primary active transport in E. coli in terms of “pumping” of protons out of the bacterial cell, including in very general terms where the energy comes from for transporting protons from lower to higher concentration. 10. Describe lactose transport into E. coli against its concentration gradient (unfavorable direction) as an example of secondary active transport, including the favorable process that provides the free energy needed to drive the “uphill” lactose transport. 11. BrieFy describe the structure and function of the insulin receptor, including the location and nature of its enzymatic activity when it is activated by insulin binding.
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Lipids Lipids Lipids: Lipids: organic compounds that are insoluble in water, soluble in organic solvents Major functions: energy storage and components of biological membranes Other important functions: signals, electron carriers Open chain compounds with long non-polar tails Triacylglycerols: glycerol backbone + 3 fatty acids (esters)
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This note was uploaded on 02/25/2009 for the course BCH 100 taught by Professor Staff during the Spring '08 term at UC Riverside.

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ZieglerLecture8-Lipids-Mbrs-ppt1 - Lecture 8: Lipids and...

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