lect9 - Bio 1A. Feb. 9, 2009 Lecture 9. Wilt Glycolysis and...

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Bio 1A. Feb. 9, 2009 Lecture 9. Wilt Glycolysis and the Krebs Cycle I. Glycolysis ( 10 steps) A. Food, mainly in the form of fats and carbs's is digested and converted, if need be, to glucose. Glucose is processed by glycolysis anaerobically to produce 2 ATP and 2 NADH per glucose molecule. B. Fig. 9.8 gives a good overview of the process. Note that the first 5 reactions result in the addition of 2 ATP molecules to each hexose. Transfer of phosphate from ATP to substrate is phosphorylation . Enzymes that do this are called kinases . The C-6 back bone is converted to two 3 carbon ( 3C) molecules. C. The second 5 reactions result in formation of 4 ATP molecules; the energy rich γ -phosphate of ATP is captured from substate molecules. This is called substrate level phosphorylation. There is also an oxidation resulting in reduction of 2 NAD+ molecules to form 2 NADH for every glucose molecule. D. Fig. 9.9 gives more detail that we expect. You should, however, know the structures of : glucose, glyceraldehyde-3-phosphate, phospho-enol pyruvate,
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lect9 - Bio 1A. Feb. 9, 2009 Lecture 9. Wilt Glycolysis and...

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