Transmission genetics 2

Transmission genetics 2 - Transmission genetics based on...

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Transmission genetics – based on the extension and modification Molecular genetics What are genes made of? How doe genes work? Requirements for the hereditary material o Precisely duplicated and transmitted to the next generation o Serves as a system of information storage and retrieval 1944 o Avery, Macleod and McCarty at Rockefeller University o Demonstrated that the “transforming factor” in bacteria is DNA o Griffith’s transformation Experiment 1928 Griffith’s bacterial strains o S strain – virulent – form smooth colonies because cells have a polysaccharide capsule – can’t be phagocytized o R strain – a virulent – form rough colonies Transformation o Living s cells were obtained from the dead mice that had been rejected with dead S cells and living R cells o Conclusion – some substances from the dead S cells had been transferred to the living R cells and transformed them into S cells 1944 o Aver Macleod McCarty o Treated R strain bacteria with highly purified DNA groom S strain bacteria
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Transmission genetics 2 - Transmission genetics based on...

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