Chapter 6 - CHAPTER 6: Interactions Between Cells & the...

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Unformatted text preview: CHAPTER 6: Interactions Between Cells & the Extracellular Environment K. Wells VPHY3100: Elements of Physiology Dept. Physiology & Pharmacology College Vet. Med. Wells/VPHY3100 Lecture outline The cell: inside & out The extracellular environment Movement through the cell membrane: diffusion & osmosis Movement through the cell membrane: carrier-mediated transport Movement via vesicular fusion The membrane potential Cell signaling The cell FIGURE 3.1 http://catalog.nucleusinc.com/generateexhibit.php?ID=14600 http://www.biochem.mpg.de/en/rd/fromherz/publications/99vasfro/ http://original.britannica.com/eb/art-56763/ Some real cells Wells/VPHY3100 The cell: inside & out The cell Cytoplasm Cytosol Organelles Nucleus Cell (or plasma) membrane The extracellular space FIGURE 3.2 Inside of cell Outside of cell Wells/VPHY3100 Lecture outline The cell: inside & out The extracellular environment Movement through the cell membrane: diffusion & osmosis Movement through the cell membrane: carrier-mediated transport Movement via vesicular fusion The membrane potential Cell signaling Wells/VPHY3100 The extracellular environment The cell membrane acts as a physical barrier between the cytoplasm (inside of the cell) and the extracellular fluid (ECF, outside of the cell) Living organisms are 70% water by weight! Total body water is divided between: Intracellular compartments (~67%) Extracellular compartments (~33%) 20% as vascular fluid (blood plasma) 80% as interstitial fluid (non-vascular tissue fluid that resides within the extracellular matrix) Wells/VPHY3100 Extracellular & intracellular compartments FIGURE 14.8 The extracellular environment The extracellular environment includes everything that lies outside of cells The ECM, or extracellular matrix: Gel-like hydrated material Ground substance Glycoproteins (such as integrins) Proteoglycans Protein fibers Collagen Elastin Selective permeability of cell membranes Simple diffusion Carrier- mediated transport Lodish et al., Molecular Cell Biology, 5th Ed. Wells/VPHY3100 Lecture outline The cell: inside & out The extracellular environment Movement through the cell membrane: diffusion & osmosis Movement through the cell membrane: carrier-mediated transport Movement via vesicular fusion The membrane potential Cell signaling Wells/VPHY3100 Solutions & Diffusion Biological systems are water- based Aqueous solutions Solvent = water Solute = stuff dissolved in water Concentration tells us the amount of solute relative to the amount of solution (or solvent) Concentration differences (gradients) lead to the downhill net diffusion of solute from the region of higher concentration to the region of lower concentration FIGURE 6.2 Simple diffusion...
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This note was uploaded on 02/28/2009 for the course VPHY 3100 taught by Professor W during the Spring '05 term at University of Georgia Athens.

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Chapter 6 - CHAPTER 6: Interactions Between Cells & the...

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