Neurotransmission - Neurotransmission 00:26:00 Synthesis...

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Neurotransmission 08/02/2009 01:26:00 Synthesis, Transport, and Storage of Neurotransmitters Neurotransmitter – chemical/gas/hormone synthesized and released from  neurons o Large – peptides. Made in cell body and than transported down axon  to terminal o Small – amino acids, monoamines, and gases. Made in terminals In terminal, most neurotransmitters stored in membranes called vesicles Release of neurotransmitters occurs when vesicles “dump” neurotransmitters  into synaptic cleft Neurotransmission - Exocytosis 1. Action potential travels down axon of neuron  2. Depolarization of membrane, activates voltage-gated Ca2+ channels ->  Ca2+ enters 3. Ca2+ stimulates vesicles to move to “active zone” -> where vesicles dock  prior to release  4. Vesicle membrane fuses with cell membrane in active zone and  neurotransmitters are released into synaptic cleft 5. Interact with receptors on postsynaptic neuron -> PSPs small - released in pulses when Ca2+ signal is sent large – released when there is higher rates of firing and Ca2+ levels rise in  terminal
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