Lecture3 - Psychopharmacology Families of Transmitters(Table 4.1 Amines Quarternary amines acetylcholine Monoamines a Catecholamines norepinephrine

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1 Psychopharmacology Families of Transmitters (Table 4.1) Amines Quarternary amines: acetylcholine Monoamines: a. Catecholamines – norepinephrine, epinephrine, dopamine b. Indoleamines – serotonin, melatonin Families of Transmitters Amino acids GABA Glutamate Glycine Histamine Aspartate
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2 Families of Transmitters Peptides Opioid peptides (e.g. endorphins) Substance P, neuropeptide Y Oxytocin, vasopressin Gases Nitric oxide, carbon monoxide Acetylcholine (ACh) z Quarternary amine z The first neurotransmitter to be identified (1921) z Acetylcholine is distributed via cholinergic nerve cells in the brain z Two main types of cholinergic receptors: a. nicotonic b. muscarinic ACh z Ach is implicated in learning and memory functions z 2 reasons: a. cholinergic cells in the basal forebrain are often destroyed in people with Alzheimer’s; b. drugs that block Ach have deleterious effects on learning and memory z Also implicated in sleep regulation
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3 Dopamine (DA) z Catecholamine subclass of monoamines z Dopaminergic neurons found in many parts of the brain, including: The mesostriatal system (a.k.a. nigrostriatal) The mesolimbocortical system z Several subtypes of DA receptors (D1, D2, D3, D4, D5) DA Mesostriatal system: z Originates in substantia nigra (part of the midbrain) and extends to the striatum z Thought to play a role in motor control z Loss of neurons in this system, due to aging or drug use, may result in loss of motor control (e.g. resting tremors) z Implicated in Parkinson’s disease Treatment with L-DOPA
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4 DA Mesolimbocortical system: z Originates in ventral tegmental area (midbrain) and projects to the limbic system and the cortex z Involved in schizophrenia? z Reward and reinforcement system Norepinephrine z Catecholamine z Also known as noradrenaline z Noradrenergic cells are found in clusters in: the pons (locus coeruleus complex) the midbrain (lateral tegmental system) medulla (dorsal medullary group)
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5 NE z Distribution of pathways extends broadly throughout the brain z NE involved in many important behavioral and psychological processes z Implicated in many processes including
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This note was uploaded on 03/01/2009 for the course PSC 121 taught by Professor Henry during the Spring '08 term at UC Davis.

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Lecture3 - Psychopharmacology Families of Transmitters(Table 4.1 Amines Quarternary amines acetylcholine Monoamines a Catecholamines norepinephrine

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