lecture3 - Psychopharmacology Families of...

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1 Psychopharmacology Families of Transmitters (Table 4.1) Amines Quarternary amines: acetylcholine Monoamines: a. Catecholamines – norepinephrine, epinephrine, dopamine b. Indoleamines – serotonin, melatonin Families of Transmitters Amino acids GABA Glutamate Glycine Histamine Aspartate
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2 Families of Transmitters Peptides Opioid peptides (e.g. endorphins) Substance P, neuropeptide Y Oxytocin, vasopressin Gases Nitric oxide, carbon monoxide Acetylcholine (ACh) z Quarternary amine z The first neurotransmitter to be identified (1921) z Acetylcholine is distributed via cholinergic nerve cells in the brain z Two main types of cholinergic receptors: a. nicotonic b. muscarinic ACh z Ach is implicated in learning and memory functions z 2 reasons: a. cholinergic cells in the basal forebrain are often destroyed in people with Alzheimer’s; b. drugs that block Ach have deleterious effects on learning and memory z Also implicated in sleep regulation
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