Hankenson #1 - ExtracellularMatrix...

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Extracellular Matrix Kurt D. Hankenson, D.V.M., Ph.D. Orthopaedic Research Laboratories kdhank@umich.edu
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DAY 1 Generalized overview Collagens Collagen related diseases DAY 2 Elastin Proteoglycans Matricellular proteins Adhesive proteins Extracellular enzymes DAY 3 Cell adhesion Mechanical transduction Specialized structures
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Extracellular Matrix Extracellular - outside the cell
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Extracellular Matrix Extracellular - outside the cell Matrix - “a surrounding substance within which something originates, develops, or is contained”
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Extracellular Matrix A notable difference between unicellular and multicellular organisms is the presence of an extracellular matrix.
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Extracellular Matrix A notable difference between unicellular and multicellular organisms is the presence of an extracellular matrix. With increasing physiological complexity the number of gene family members and homologs for ECM domains increases. Post-genomic analysis » example… properdin domain of thrombospondins, more than 40 in mouse…less than 5 in fruit fly
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Extracellular Matrix Where is it? Extracellular space Surrounds the cells that secrete it
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Extracellular Matrix Where is it? Extracellular space Surrounds the cells that secrete it Most (all) tissues/organs contain some amount of ECM » ex. Endothelium with basement membranes
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Extracellular Matrix Where is it? Extracellular space Surrounds the cells that secrete it Most (all) tissues/organs contain some amount of ECM » ex. Endothelium with basement membranes Plentiful in connective tissues
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Extracellular Matrix Connective tissues Architectural framework of the vertebrate body More matrix than cells (generally)
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Extracellular Matrix Connective tissues: Bone Tendon/ligament Cartilage Blood (specialized) Fibrous exteriors of parenchymous organs
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Extracellular Matrix Connective tissue based organs: Functional adaptation to physiologic demands » Bone matrix is calcified
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Bone ECM
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Connective tissue based organs:
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Hankenson #1 - ExtracellularMatrix...

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